Immunostaining to determine osteocyte apoptosis by caspase‐3
نویسندگان
چکیده
منابع مشابه
Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis.
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Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activi...
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GAP JUNCTIONS ARE arrays of transcellular channels that allow aqueous continuity between the cytoplasms of two adjacent cells. A gap junction channel is established by docking of two “hemichannels” or connexons present on juxtaposed cells, thus forming a transcellular conduit through which ions and small molecules can diffuse from cell to cell. Each connexon is composed of a hexameric array of ...
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PURPOSE The purpose of this study was to determine whether bisphosphonate treatment can prevent or delay osteocyte apoptosis in a cyclic fatigue animal model and if there are differences between two different bisphosphonates in their effects on osteocyte apoptosis. INTRODUCTION Fatigue loading induces microdamage in long bones in rats and causes osteocyte apoptosis. In vitro data suggest that...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a24-c